Abstract | OBJECTIVE: METHODS: We describe the clinical, imaging, and laboratory findings of the patient and review the relevant literature regarding OART and the possible interaction between ACTH and brown adipose tissue. RESULTS: An 18-year-old female with congenital adrenal hyperplasia, who had undergone bilateral adrenalectomy at the age of 10 years, presented with severe hyperpigmentation and hirsutism. Rectal ultrasonography showed a mass in the right ovary. (18)F-fluorodeoxyglucose PET/CT revealed intense uptake both in this mass and in brown adipose tissue located in typical supradiaphragmatic sites. Laparoscopic removal of the ovarian mass confirmed the diagnosis of OART. A systematic review revealed 9 documented cases of OART. As in our case, all presented with elevated ACTH levels. CONCLUSIONS: Common to all documented cases of OART are sustained high ACTH levels that activate the adrenal anlagen tissue in the ovaries.
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Authors | Dov Tiosano, Euvgeni Vlodavsky, Shlomo Filmar, Zeev Weiner, Dorit Goldsher, Rachel Bar-Shalom |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 74
Issue 3
Pg. 223-8
( 2010)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 20431278
(Publication Type: Case Reports, Journal Article)
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Copyright | 2010 S. Karger AG, Basel. |
Chemical References |
- Adrenocorticotropic Hormone
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Topics |
- Adolescent
- Adrenal Hyperplasia, Congenital
(blood, complications, surgery)
- Adrenal Rest Tumor
(blood, complications)
- Adrenalectomy
- Adrenocorticotropic Hormone
(blood)
- Female
- Humans
- Nelson Syndrome
(blood)
- Ovarian Neoplasms
(blood, complications)
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