Enhancing chemotherapeutic drug inhibition on tumor growth by ultrasound: an in vivo experiment.
|
| Abstract |
An in vivo study on enhancing epirubicin hydrochloride (EPI) inhibition on tumor growth by ultrasound (US) was reported. Five-week-old male nude mice were used and HL-60 cells were s.c. (subcutaneous injection) inoculated in axilla of these mice. Six groups were designed and five consecutive treatments were applied to investigate the inhibition on tumor growth and body weight growth. US applied locally to the tumor resulted in a substantially increased drug uptake in tumor cells. The inhibition on tumor growth depended on the position of drug injection and phospholipid-based microbubble (PMB) application. Tumor growth rate under group 1 (PMB+US) was similar to that of blank control. The order of the inhibition on tumor volume growth was: group 4 (s.c. EPI+PMB+US) > group 5 intraperitoneal (i.p. EPI+PMB+US) > group 2 (i.p. EPI) > group 3 (s.c. EPI+US) > group 1 (PMB+US). Similar conclusion was obtained from experimental measurements of tumor weight change. The order of animal survival status for EPI administration groups was: group 4 > group 5 > group 2 > group 3. Chemotherapeutic drug inhibition on tumor growth could be enhanced by local US combined with PMB, which might provide a potential application for US-mediated chemotherapy.
|
|---|---|
| Authors | Ying-Zheng Zhao, Cui-Tao Lu, Zhi-Cai Zhou, Zhuo Jin, Lu Zhang, Chang-Zheng Sun, Yan-Yan Xu, Hui-Sheng Gao, Ji-Lai Tian, Feng-Hou Gao, Qin-Qin Tang, Wei Li, Qi Xiang, Xiao-Kun Li, Wen-Feng Li |
| Journal | Journal of drug targeting (J Drug Target) Vol. 19 Issue 2 Pg. 154-60 (Feb 2011) ISSN: 1029-2330 [Electronic] England |
| PMID | 20429773 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!