Abstract | BACKGROUND: Microsusceptibility changes in the brain are well known to correspond with microbleeds or micrometal fragments in adults, but this phenomenon has not been explored well in children. OBJECTIVE: To assess imaging and clinical characteristics of children with multiple foci of microsusceptibility changes using susceptibility-weighted imaging (SWI). MATERIALS AND METHODS: Between 2006 and 2008, 12 children with multiple foci of microsusceptibility on SWI without corresponding abnormal signal on conventional MRI were identified and were retrospectively assessed. RESULTS: The locations of foci of microsusceptibility included the cerebral white matter, basal ganglia, brainstem and cerebellar white matter, without any clear systematic anatomic distribution. CT (n=5) showed no calcification at the locations corresponding to the microsusceptibility on SWI. Conventional MR imaging showed white matter volume loss (n=5), delayed myelination (n=2), acute infarction (n=1), chronic infarction (n=1), meningitis (n=1), slight signal abnormality in the white matter (n=1) and no abnormal findings (n=1). Follow-up SWI (n=3) showed no change of the microsusceptibility foci. Interestingly, all children had a history of heart surgery under extracorporeal circulation for congenital heart disease. CONCLUSION:
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Authors | Tetsu Niwa, Noriko Aida, Taro Takahara, Thomas C Kwee, Kazutoshi Fujita, Ayako Shishikura, Daiki Miyata, Tomio Inoue |
Journal | Pediatric radiology
(Pediatr Radiol)
Vol. 40
Issue 10
Pg. 1657-62
(Oct 2010)
ISSN: 1432-1998 [Electronic] Germany |
PMID | 20425108
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Brain
(pathology)
- Child
- Child, Preschool
- Humans
- Intracranial Hemorrhages
(diagnosis)
- Magnetic Resonance Angiography
- Retrospective Studies
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