Abstract | BACKGROUND: OBJECTIVES: RESULTS: Acute fasting decreased body temperature late at night accompanied by the induction of hepatic FGF21 and hypothalamic NPY expression in wild-type mice. A deficiency of FGF21 affected neither fasting- induced hypothermia nor hypothalamic NPY induction. Fasting enhanced locomotor activity in both genotypes. On the other hand, a deficiency of FGF21 significantly attenuated chronic hypothermia and hypoactivity induced by a ketogenic diet (KD). CONCLUSIONS: Our findings suggest that FGF21 is not essential for the hypothermia that is associated with the early stages of fasting, although it might be involved in the adaptive response of body temperature to chronic starvation.
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Authors | Katsutaka Oishi, Katsuhiko Sakamoto, Morichika Konishi, Yusuke Murata, Nobuyuki Itoh, Hiroyoshi Sei |
Journal | Neuro endocrinology letters
(Neuro Endocrinol Lett)
Vol. 31
Issue 2
Pg. 198-202
( 2010)
ISSN: 0172-780X [Print] Sweden |
PMID | 20424589
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuropeptide Y
- RNA, Messenger
- fibroblast growth factor 21
- Fibroblast Growth Factors
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Topics |
- Animals
- Body Temperature
- Diet, Ketogenic
(methods)
- Fasting
(adverse effects, metabolism)
- Fibroblast Growth Factors
(deficiency, genetics, metabolism)
- Hypothalamus
(metabolism)
- Hypothermia
(etiology, metabolism)
- Liver
(metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Motor Activity
- Neuropeptide Y
(genetics, metabolism)
- RNA, Messenger
(metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
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