Efficacy of milrinone versus nitroglycerin in controlling pulmonary arterial hypertension induced by intravenous injections of absolute ethanol in anesthetized dogs.

Abstract

PURPOSE:

To compare the attenuating effects of milrinone versus nitroglycerin on pulmonary artery pressure (PAP) increase caused by repeat intravenous bolus injection of absolute ethanol in anesthetized dogs.

MATERIALS AND METHODS:

Twenty-four dogs were randomly distributed into three groups: a control group (group C), a nitroglycerin group (treated with a continuous infusion of nitroglycerin at 5.0 microg/kg/min; group N), and a milrinone group (treated with a continuous infusion of milrinone at 3.0 microg/kg/min after an initial bolus dose of 100 microg/kg; group M). Absolute ethanol (0.1 mL/kg) was injected at 10-minute intervals via a 5-F angiographic catheter advanced into the proximal portion of the inferior vena cava. Immediately before and after each intravenous injection of absolute ethanol, hemodynamic values were obtained through a pulmonary arterial catheter.

RESULTS:

Group M showed more stable hemodynamic values of systolic, mean, and diastolic PAP and pulmonary vascular resistance (PVR) compared with groups C and N. In addition, group M showed significantly higher values of cardiac output versus group C at 10 minutes after the 10th bolus of ethanol. After restoration of spontaneous breathing, group M also showed the least hemodynamic changes in systolic, mean, and diastolic PAPs and PVR among the groups.

CONCLUSIONS:

Although a continuous infusion of nitroglycerin or milrinone effectively prevented cardiovascular deterioration, milrinone was superior to nitroglycerin in managing the acute hemodynamic changes that resulted from repeated intravenous bolus injections of absolute ethanol (0.1 mL/kg) in healthy anesthetized dogs.

• Authors: Jong Sung Kim, Mi Hyun Nam, Young Soo Do, Chul Joong Lee, Chung Su Kim, Woo Seok Sim, Kwang Bo Park, Sang Hyun Lee, Jin Soo Han, Byung Seop Shin, Hwi Yool Kim
• Journal: Journal of vascular and interventional radiology : JVIR (J Vasc Interv Radiol) Vol. 21 Issue 6 Pg. 882-7 (Jun 2010) ISSN: 1535-7732 [Electronic] United States
• PMID: 20418111 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2010 SIR. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antihypertensive Agents
• Sclerosing Solutions
• Ethanol
• Nitroglycerin
• Milrinone

Topics

• Animals
• Antihypertensive Agents (administration & dosage)
• Dogs
• Ethanol (administration & dosage, adverse effects)
• Female
• Hypertension, Pulmonary (chemically induced, prevention & control)
• Injections, Intravenous (adverse effects)
• Male
• Milrinone (administration & dosage)
• Nitroglycerin (administration & dosage)
• Sclerosing Solutions (adverse effects)
• Treatment Outcome