A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects.

Abstract

We examined the association of schizophrenia (SCZ) and dihydropyrimidinase-like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.

• Authors: Takayoshi Koide, Branko Aleksic, Yoshihito Ito, Hinako Usui, Akira Yoshimi, Toshiya Inada, Michio Suzuki, Ryota Hashimoto, Masatoshi Takeda, Nakao Iwata, Norio Ozaki
• Journal: Journal of human genetics (J Hum Genet) Vol. 55 Issue 7 Pg. 469-72 (Jul 2010) ISSN: 1435-232X [Electronic] England
• PMID: 20414250 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Intercellular Signaling Peptides and Proteins
• Nerve Tissue Proteins
• collapsin response mediator protein-2

Topics

• Adult
• Alleles
• Asian People (genetics)
• Case-Control Studies
• Female
• Gene Frequency (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genetic Testing
• Humans
• Intercellular Signaling Peptides and Proteins (genetics)
• Japan
• Male
• Nerve Tissue Proteins (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Schizophrenia (enzymology, genetics)