Mechanisms underlying the effects of ultralow doses of antibodies to granulocytic colony-stimulating factor on recovery of damaged pancreatic tissue in experimental diabetes mellitus.

Abstract

Using the model of alloxan-induced diabetes mellitus on rats we demonstrated the effect of ultralow doses of antibodies to granulocytic colony-stimulating factor on recovery of the pancreas and normalization of blood glucose concentration. The preparation produced an antiinflammatory and antisclerotic effects associated with activation of stem cells and their determined homing into the pancreas.

• Authors: N N Ermakova, V V Zhdanov, A M Dygai, G N Zyuz'kov, L A Stavrova, L A Gur'yantseva, T Yu Khrichkova, E V Udut, T V Vetoshkina, T I Fomina, L A Ermolaeva, E D Goldberg
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 148 Issue 3 Pg. 549-52 (Sep 2009) ISSN: 1573-8221 [Electronic] United States
• PMID: 20396738 (Publication Type: Journal Article)

Chemical References

• Antibodies
• Granulocyte Colony-Stimulating Factor

Topics

• Animals
• Antibodies (immunology, therapeutic use)
• Diabetes Mellitus, Experimental (drug therapy, pathology)
• Female
• Granulocyte Colony-Stimulating Factor (immunology)
• Male
• Mice
• Mice, Inbred CBA
• Pancreas (drug effects, pathology)