[A case of cytokeratin 19 positive extramammary Paget's disease with pulmonary metastases].

Abstract

An 82-year-old woman was admitted because of progressing cough and dyspnea. Two years prior to admission, she had undergone an operation for extramammary Paget's disease which resected the primary lesion, the left labium majora, and ipsilateral inguinal and obturator lymph nodes. Thoracic images showed diffuse infiltrative shadows and bilateral effusions. Repeated thoracenteses revealed no microbes or malignant cells. Antibiotic treatment was ineffective. Transbronchial lung biopsy specimens revealed Paget cells, and immunohistochemical stains confirmed pulmonary metastases of Paget's disease. Cytokeratin 19 fragments were positive in the serum, pleural effusion, and lung biopsy specimens. The patient died of respiratory failure 3 years after the initial diagnosis of extramammary Paget's disease.

• Authors: Kunio Hamada, Norihiro Onuma
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 48 Issue 3 Pg. 204-9 (Mar 2010) ISSN: 1343-3490 [Print] Japan
• PMID: 20387524 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Keratin-19

Topics

• Aged, 80 and over
• Female
• Genital Neoplasms, Female (pathology)
• Humans
• Keratin-19 (blood)
• Lung Neoplasms (secondary)
• Lymphatic Metastasis
• Paget Disease, Extramammary (pathology)