Regression of primary central nervous system germinoma after dexamethasone administration: a case report.

Abstract

Childhood central nervous system (CNS) germinoma are highly curable brain tumors characterized pathologically by varying degrees of lymphocytic infiltration. The authors present a case of a CNS germinoma with significant regression in size following surgery and administration of dexamethasone, prior to initiation of chemotherapy or irradiation. The authors speculate the possible mechanism involved in its occurrence. Perioperative corticosteroid administration in patients with CNS germinoma may obfuscate the increase in response demonstrated with various chemotherapy regimens or with irradiation in CNS germinomas.

• Authors: Stephanie J Si, Soumen Khatua, Girish Dhall, Marvin D Nelson, Ignacio Gonzalez-Gomez, Jonathan L Finlay
• Journal: Pediatric hematology and oncology (Pediatr Hematol Oncol) Vol. 27 Issue 3 Pg. 237-43 (Apr 2010) ISSN: 1521-0669 [Electronic] England
• PMID: 20367268 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dexamethasone

Topics

• Adolescent
• Brain Neoplasms (drug therapy, pathology)
• Dexamethasone (therapeutic use)
• Germinoma (drug therapy, pathology)
• Humans
• Magnetic Resonance Imaging
• Male