Abstract | BACKGROUND: OBJECTIVES: To investigate the association between FLG null mutations and ( nickel) contact sensitization. METHODS: A random sample of 3335 adults from the general population in Denmark was patch tested and genotyped for R501X and 2282del4 in the FLG gene. RESULTS: The combined carrier frequency of FLG null mutations was 8·1%. Nickel, fragrance and contact sensitization to at least one allergen were not associated with FLG null mutations. A crude analysis on women who did not have ear piercings revealed a positive association between FLG null mutations and nickel sensitization [8·3% vs. 2·4%; odds ratio (OR) 3·71, 95% confidence interval (CI) 0·73-18·96] as well as between FLG null mutations and allergic nickel dermatitis (8·3% vs. 1·3%; OR 6·75, 95% CI 1·17-38·91). FLG mutation status and atopic dermatitis were positively associated with neomycin or ethylenediamine sensitization. CONCLUSIONS: This study suggests that FLG null mutations may be a risk factor for the development of nickel sensitization. However, ear piercing was a much stronger risk factor in our general population and we could therefore identify a positive association only in women without ear piercings. Contact sensitization to specific chemicals is related to treatment exposure.
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Authors | J P Thyssen, J D Johansen, A Linneberg, T Menné, N H Nielsen, M Meldgaard, P B Szecsi, S Stender, B C Carlsen |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 162
Issue 6
Pg. 1278-85
(Jun 2010)
ISSN: 1365-2133 [Electronic] England |
PMID | 20346018
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 The Authors. Journal Compilation © 2010 British Association of Dermatologists. |
Chemical References |
- Ethylenediamines
- FLG protein, human
- Filaggrin Proteins
- Intermediate Filament Proteins
- Immunoglobulin E
- ethylenediamine
- Nickel
- Neomycin
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Topics |
- Adolescent
- Adult
- Aged
- Cross-Sectional Studies
- Denmark
- Dermatitis, Atopic
(genetics, immunology)
- Ethylenediamines
(adverse effects)
- Female
- Filaggrin Proteins
- Gene Frequency
- Genotype
- Humans
- Immunoglobulin E
(analysis)
- Intermediate Filament Proteins
(genetics)
- Male
- Middle Aged
- Neomycin
(adverse effects)
- Nickel
(immunology, toxicity)
- Young Adult
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