Specific profiles of house dust mite sensitization in children with asthma and in children with eczema.

Abstract

Sensitization to house dust mites (HDM) is highly prevalent among the young atopic population in Singapore. Previously published data suggest that individuals with skin allergies show preferred sensitization to Dermatophagoides pteronyssinus while individuals with pure respiratory allergies show preferred sensitization to Blomia tropicalis. The aim of our study was to compare the sensitization profiles between children with asthma and those with eczema to D. pteronyssinus and B. tropicalis and their specific allergens. A total of 60 children, 30 with asthma and 30 with eczema were recruited. IgE levels specific for a panel of HDM allergens from the two mite species were measured using enzyme-linked immunosorbent assay. The asthma group showed highest sensitization to Blo t5 while the eczema group showed highest sensitization to Der p5. Comparison between the two disease groups showed that the eczema group had significantly higher IgE levels for Der p (p = 0.042) and its allergens Der p1 (p = 0.019) and Der p5 (p = 0.001). Generally, the eczema group was more sensitized to the panel of allergens compared to the asthma group. Individuals with asthma and those with eczema showed different sensitization profiles to HDM. These findings highlighted possible mechanisms for different manifestation of allergy.

• Authors: Lynette Pei-Chi Shek, Angeline R Chong, Shu E Soh, Nge Cheong, Audrey S M Teo, Fong C Yi, Yoke C Giam, Kaw Y Chua, Hugo P Van Bever
• Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (Pediatr Allergy Immunol) Vol. 21 Issue 4 Pt 2 Pg. e718-22 (Jun 2010) ISSN: 1399-3038 [Electronic] England
• PMID: 20337963 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Allergens
• Antigens, Dermatophagoides
• Antigens, Plant
• Arthropod Proteins
• Dermatophagoides pteronyssinus antigen p 5
• allergen Blo t 5
• Immunoglobulin E
• Cysteine Endopeptidases
• Dermatophagoides pteronyssinus antigen p 1

Topics

• Adolescent
• Allergens
• Animals
• Antigens, Dermatophagoides (immunology)
• Antigens, Plant (immunology)
• Arthropod Proteins
• Asthma (blood, diagnosis, immunology, physiopathology)
• Child
• Cysteine Endopeptidases
• Eczema (blood, diagnosis, immunology, physiopathology)
• Exanthema
• Female
• Humans
• Immunization
• Immunoglobulin E (blood, immunology)
• Male
• Pyroglyphidae
• Respiratory Sounds