Sleep and rhythm consequences of a genetically induced loss of serotonin.
Abstract | BACKGROUND: OBJECTIVE: PATIENT: METHODS: RESULTS: Before treatment, the patient had mild hypersomnia with long sleep time (704 min), ultradian sleep-wake rhythm (sleep occurred every 11.8 +/- 5.3 h), organic hyperphagia, attentionlexecutive dysfunction, and no depression. The serotonin metabolism in the CSF was reduced, and the serum melatonin profile was flat, while cortisol and core temperature profiles were normal. Supplementation with 5-hydroxytryptophan, but not with levodopa, normalized serotonin metabolism in the CSF, reduced sleep time to 540 min, normalized the eating disorder and the melatonin profile, restored a circadian sleep-wake rhythm (sleep occurred every 24 +/- 1.7 h, P < 0.0001), and improved cognition. CONCLUSION: In this unique genetic paradigm, the melatonin deficiency (caused by a lack of its substrate, serotonin) may cause the ultradian sleep-wake rhythm.
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Authors | Smaranda Leu-Semenescu, Isabelle Arnulf, Caroline Decaix, Fathi Moussa, Fabienne Clot, Camille Boniol, Yvan Touitou, Richard Levy, Marie Vidailhet, Emmanuel Roze |
Journal | Sleep
(Sleep)
Vol. 33
Issue 3
Pg. 307-14
(Mar 2010)
ISSN: 0161-8105 [Print] United States |
PMID | 20337188
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antidepressive Agents, Second-Generation
- Dopamine Agents
- Serotonin
- Levodopa
- 5-Hydroxytryptophan
- Alcohol Oxidoreductases
- sepiapterin reductase
- Melatonin
- Dopamine
- Hydrocortisone
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Topics |
- 5-Hydroxytryptophan
(therapeutic use)
- Adult
- Alcohol Oxidoreductases
(deficiency, genetics)
- Antidepressive Agents, Second-Generation
(therapeutic use)
- Consanguinity
- Disorders of Excessive Somnolence
(drug therapy, enzymology, genetics)
- Dopamine
(deficiency)
- Dopamine Agents
(therapeutic use)
- Drug Therapy, Combination
- Humans
- Hydrocortisone
(blood)
- Hyperphagia
(drug therapy, enzymology, genetics)
- Levodopa
(therapeutic use)
- Male
- Melatonin
(deficiency)
- Polysomnography
- Serotonin
(deficiency)
- Sleep
(drug effects, genetics)
- Sleep Disorders, Circadian Rhythm
(drug therapy, enzymology, genetics)
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