Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

Abstract

Three new flavonoids, (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate (1), (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]chrysin (2), and (7''R)-8-[1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl]galangin (3), together with 41 known compounds (4-44) were isolated from a methanolic extract of Mexican propolis. Compounds 2 and 3 are unique natural flavones containing a 1-phenylallyl moiety. The in vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compound 3 displayed the most potent preferential cytotoxicity (PC(50) 4.6 microM) in the nutrient-deprived medium (NDM) and triggered apoptosis-like morphological changes in PANC-1 cells.

• Authors: Feng Li, Suresh Awale, Yasuhiro Tezuka, Hiroyasu Esumi, Shigetoshi Kadota
• Journal: Journal of natural products (J Nat Prod) Vol. 73 Issue 4 Pg. 623-7 (Apr 23 2010) ISSN: 1520-6025 [Electronic] United States
• PMID: 20307087 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• (2R,3R)-3,5-dihydroxy-7-methoxyflavanone 3-(2-methyl)butyrate
• (7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)chrysin
• (7''R)-8-(1-(4'-hydroxy-3'-methoxyphenyl)prop-2-en-1-yl)galangin
• Antineoplastic Agents
• Flavonoids
• Propolis

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Apoptosis (physiology)
• Bees
• Drug Screening Assays, Antitumor
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Humans
• Mexico
• Molecular Structure
• Pancreatic Neoplasms (drug therapy)
• Propolis (chemistry, pharmacology)
• Stereoisomerism