Clinical significance of the ratio between the alpha 2 plasmin inhibitor-plasmin complex and the thrombin-antithrombin complex in advanced non-small cell lung cancer.

Abstract

The aims of this study are to: (a) confirm the prognostic significance of the procoagulant molecules D dimer, thrombin-antithrombin complex (TAT), and plasmin-α2-plasmin inhibitor complex (PIC); (b) to evaluate hemostatic activation in patients with advanced non-small cell lung cancer (NSCLC); and (c) to delineate the relationships between markers of hemostasis and other clinical characteristics. In this study, a low PIC/TAT ratio and poor PS were significant independent negative prognostic factors for survival in patients with advanced NSCLC. The PIC/TAT ratio may become a surrogate marker for treatment with anticoagulants in the future.

• Authors: Katsuhiro Masago, Shiro Fujita, Tadashi Mio, Yosuke Togashi, Young Hak Kim, Yukimasa Hatachi, Akiko Fukuhara, Kaoru Irisa, Yuichi Sakamori, Michiaki Mishima
• Journal: Medical oncology (Northwood, London, England) (Med Oncol) Vol. 28 Issue 1 Pg. 351-6 (Mar 2011) ISSN: 1559-131X [Electronic] United States
• PMID: 20300980 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• alpha-2-Antiplasmin
• antithrombin III-protease complex
• plasmin-plasmin inhibitor complex
• Antithrombin III
• Peptide Hydrolases
• Fibrinolysin

Topics

• Adenocarcinoma (blood, mortality, therapy)
• Adult
• Aged
• Aged, 80 and over
• Antithrombin III (metabolism)
• Biomarkers, Tumor (blood)
• Blood Coagulation
• Carcinoma, Non-Small-Cell Lung (blood, mortality, therapy)
• Carcinoma, Squamous Cell (blood, mortality, therapy)
• Female
• Fibrinolysin (metabolism)
• Humans
• Lung Neoplasms (blood, mortality, therapy)
• Male
• Middle Aged
• Peptide Hydrolases (metabolism)
• Prognosis
• Survival Rate
• alpha-2-Antiplasmin (metabolism)