Prognostic value of serum levels of interleukin-6 in patients with ST-segment elevation acute myocardial infarction.

Abstract

BACKGROUND:

Interleukin-6 (IL6) plays a role in atherogenesis as well as in most atherothrombotic phenomenon such as ST-segment elevation acute myocardial infarction (STEAMI). Our objective was to evaluate serum levels of IL6 as prognostic value for major clinical in-hospital events in patients with STEAMI.

METHODS:

We studied consecutive patients with diagnosis of STEAMI according to ACC/AHA/ESC criteria. Twenty four hours after the acute event, IL6 was determined by chemiluminescence method. The major cardiovascular end points were arrhythmias, angina, heart failure, reinfarction and death.

RESULTS:

Included were 97 patients. The level of IL6 to identify high-risk patients was 20 pg/ml. Forty six patients had <20 pg/ml (group I), and 51 patients had >20 pg/ml (group II). Mean value of IL6 was 11.52 +/- 4.83 pg/ml vs. 63.19 +/- 44.4 pg/ml (p <0.0001). Death was more frequent (2.2 vs. 15.7%, p = 0.023, RR 1.16 95% CI 1.02-1.31) and the end point combined during hospitalization in group II was 21.7 vs. 51% (p = 0.003 RR 1.59 95% CI 1.16-2.19). Multivariate logistic regression analysis identified Killip class > or = 2 and IL6 levels > or = 20 pg/ml as predictors for in-hospital end point.

CONCLUSIONS:

Serum levels of IL6 >20 pg/ml in the first 24 h after STEAMI were significantly associated with higher frequency of in-hospital outcomes such as arrhythmias and death.

• Authors: Gabriela Borrayo-Sánchez, Alex Pacheco-Bouthillier, Lorena Mendoza-Valdez, Irma Isordia-Salas, Rubén Argüero-Sánchez, Guillermo Careaga Reyna
• Journal: Cirugia y cirujanos (Cir Cir) 2010 Jan-Feb Vol. 78 Issue 1 Pg. 25-30 ISSN: 2444-054X [Electronic] Mexico
• PMID: 20226125 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Biomarkers
• IL6 protein, human
• Interleukin-6

Topics

• Aged
• Aged, 80 and over
• Angina Pectoris (epidemiology, etiology)
• Arrhythmias, Cardiac (epidemiology, etiology)
• Atherosclerosis (blood, complications)
• Biomarkers
• Diabetes Complications (blood, epidemiology)
• Electrocardiography
• Female
• Heart Failure (epidemiology, etiology)
• Hospital Mortality
• Humans
• Inflammation (blood)
• Interleukin-6 (blood)
• Male
• Middle Aged
• Myocardial Infarction (blood, complications, mortality)
• Predictive Value of Tests
• Prognosis
• Recurrence
• Risk
• Sensitivity and Specificity
• Thrombophilia (blood, etiology)