Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma.

Abstract

Peripheral T cell lymphoma not otherwise specified (PTCL-N) and ALK-negative anaplastic large cell lymphoma (ALCL) are heterogeneous categories with poor diagnostic reproducibility. To clarify the biologic features of these categories, we investigated the expression of two chemokine receptors, type 1 (Th1/Tc1)-associated CXCR3 and type 2 (Th2/Tc2)-associated CCR4 in 110 PTCL-N and 35 ALK-negative ALCL cases, as well as the expression of cytotoxic molecules (CM). CXCR3 and CCR4 were expressed in 69 (63%) and 37 (34%) of PTCL-N, and in 12 (34%) and 6 (17%) of ALK-negative ALCL, respectively. In PTCL-N, type 1 pattern (CXCR3(+)CCR4(-)) was dominant (52%), whereas in ALK-negative ALCL, 54% were negative for both (P < 0.0001). CM was expressed in 38% of PTCL-N and 51% of ALK-negative ALCL. CM-positive PTCL-N consisted mostly of type 1 disease, which shows type 1 phenotype. In contrast, type 2 pattern (CXCR3(-)CCR4(+)) was recognized in the CM-negative group only. Among type 1 disease, CM-positive cases had a higher female ratio and more aggressive clinical features than CM-negative cases and a poorer prognosis (P = 0.006). Multivariate analysis confirmed that the type 1 phenotype with CM expression was an independent prognostic factor. In both PTCL-N and ALK-negative ALCL, CM-positive type 1 disease had an extremely poor prognosis.

• Authors: Naoko Asano, Ritsuro Suzuki, Koichi Ohshima, Yoshitoyo Kagami, Fumihiro Ishida, Tadashi Yoshino, Hiroshi Ogawa, Yasuo Morishima, Shigeo Nakamura
• Journal: International journal of hematology (Int J Hematol) Vol. 91 Issue 3 Pg. 426-35 (Apr 2010) ISSN: 1865-3774 [Electronic] Japan
• PMID: 20217288 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• CCR4 protein, human
• CXCR3 protein, human
• Receptors, CCR4
• Receptors, CXCR3

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Child
• Child, Preschool
• Female
• Humans
• Immunophenotyping
• Lymphoma, Large-Cell, Anaplastic (metabolism, mortality, pathology)
• Lymphoma, T-Cell (metabolism, mortality, pathology)
• Male
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Receptors, CCR4 (metabolism)
• Receptors, CXCR3 (metabolism)
• Reed-Sternberg Cells (metabolism, pathology)
• Survival Analysis
• Th1 Cells (physiology)
• Th2 Cells (physiology)
• Young Adult