Abstract | BACKGROUND: OBJECTIVE: METHODS: Fifty-two consecutive CU patients were included in the study and disease activity was graded from 0 to 3. Plasma MMP-9, TIMP-1 and CRP levels were measured by enzyme immunoassays. Circulating histamine-releasing factors were assessed using in vivo (autologous serum skin test) and in vitro (basophil histamine release) tests. Seven CU patients were studied both during active disease and during remission. Thirty healthy subjects were used as normal controls. RESULTS: Plasma levels of MMP-9, TIMP-1 and CRP were significantly higher in CU patients than in healthy controls (P=0.0001, 0.003 and 0.005, respectively) and a trend towards a higher MMP-9/TIMP-1 molar ratio was found (P=0.051). A significant correlation was found between plasma MMP-9 levels and urticaria severity score (r=0.48, P<0.0001). CRP levels correlated with MMP-9 levels (r=0.37, P=0.008) and CU severity score (r=0.52, P=0.0001), but not with TIMP-1 (r=0.13) concentrations. MMP-9, TIMP-1 and CRP plasma levels and MMP-9/TIMP-1 molar ratio did not differ in patients either with or without an evidence of circulating histamine-releasing factors. Seven patients evaluated during remission showed a significant reduction of MMP-9 and CRP plasma levels. CONCLUSION: Plasma levels of MMP-9 and its inhibitor TIMP-1 are increased in CU patients. MMP-9 levels are associated with disease severity and CRP levels, but not with skin reactivity to autologous serum and with circulating histamine-releasing factors. These findings suggest that in CU there is an ongoing inflammatory process independent of the presence of circulating histamine-releasing factors.
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Authors | A Tedeschi, R Asero, M Lorini, A V Marzano, M Cugno |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 40
Issue 6
Pg. 875-81
(Jun 2010)
ISSN: 1365-2222 [Electronic] England |
PMID | 20214668
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Tissue Inhibitor of Metalloproteinase-1
- Tumor Protein, Translationally-Controlled 1
- C-Reactive Protein
- Matrix Metalloproteinase 9
|
Topics |
- Adult
- Biomarkers, Tumor
(blood)
- C-Reactive Protein
(metabolism)
- Chronic Disease
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Matrix Metalloproteinase 9
(blood)
- Severity of Illness Index
- Skin Tests
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Tumor Protein, Translationally-Controlled 1
- Urticaria
(blood, physiopathology)
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