[Study of methylation of promoter of EYA1 gene in microtia].

Abstract

OBJECTIVE:

To explore the methylation of CpG islands in promoter of eye absent gene 1 (EYA1) in microtia.

METHODS:

The methylation of CpG islands in EYA1 gene in 64 microtias and 36 healthy controls were measured using the technique of matrix-assisted laser desorption/ionization-time of flight.

RESULTS:

The methylation of CpG_Unit3 and CpG_Unit5 of EYA1 gene in microtia were 0.09258 +/- 0.033846 and 0.0922 +/- 0.02379, respectively, which were significantly lower than those in control.

CONCLUSIONS:

Hypomethylation in microtia may be related to the pathogenesis of the disease.

• Authors: Lin Lin, Bo Pan, Hai-yue Jiang, Hong-xing Zhuang, Yan-yong Zhao, Qing-hua Yang, Le-ren He, Juan Han, Shu-jie Wang
• Journal: Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery (Zhonghua Zheng Xing Wai Ke Za Zhi) Vol. 25 Issue 6 Pg. 436-9 (Nov 2009) ISSN: 1009-4598 [Print] China
• PMID: 20209935 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Intracellular Signaling Peptides and Proteins
• Nuclear Proteins
• EYA1 protein, human
• Protein Tyrosine Phosphatases

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• CpG Islands
• DNA Methylation
• Ear (abnormalities)
• Female
• Humans
• Intracellular Signaling Peptides and Proteins (genetics)
• Male
• Middle Aged
• Nuclear Proteins (genetics)
• Promoter Regions, Genetic
• Protein Tyrosine Phosphatases (genetics)
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
• Young Adult