Abstract |
The cerebrospinal fluid (CSF) of C57BL/6 mice infected with Angiostrongylus cantonensis was examined for kinetic changes in oxidative stress parameters, including reactive oxygen species (ROS), superoxide dismutase (SOD), catalase, malondialdehyde (MDA), 8-isoprostane, and 8-hydroxy-2'-deoxyguanosine (8-OHdG). The ROS increased gradually in the early stage of infection. During days 12-30 post- infection, the infected mice revealed ROS levels significantly higher than that in uninfected controls (P < 0.001). The ROS levels peaked at day 24 and then returned to that observed in uninfected controls at day 45 post- infection. The kinetics of MDA, 8-isoprostane, and 8-OHdG concentration changes observed in the CSF of the infected mice corresponded with kinetic changes in ROS levels. Thus, the excess ROS caused lipid peroxidation and DNA damage to cells in the central nervous system (CNS) of mice infected with A. cantonensis despite the increased antioxidant SOD and catalase enzyme activities during post- infection days 12-30. The oxidative stress in the CNS of C57BL/6 mice was apparently increased by diseases associated with A. cantonensis infection.
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Authors | Li-Yu Chung, Lian-Chen Wang, Chun-Hsiang Chen, Hsiao-Yi Lin, Chuan-Min Yen |
Journal | Redox report : communications in free radical research
(Redox Rep)
Vol. 15
Issue 1
Pg. 43-8
( 2010)
ISSN: 1743-2928 [Electronic] England |
PMID | 20196928
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Reactive Oxygen Species
- 8-epi-prostaglandin F2alpha
- Malondialdehyde
- 8-Hydroxy-2'-Deoxyguanosine
- Dinoprost
- Catalase
- Superoxide Dismutase
- Deoxyguanosine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Angiostrongylus cantonensis
- Animals
- Catalase
(cerebrospinal fluid)
- Deoxyguanosine
(analogs & derivatives, cerebrospinal fluid)
- Dinoprost
(analogs & derivatives, cerebrospinal fluid)
- Kinetics
- Malondialdehyde
(metabolism)
- Mice
- Mice, Inbred C57BL
- Oxidative Stress
(physiology)
- Reactive Oxygen Species
(metabolism)
- Strongylida Infections
(cerebrospinal fluid)
- Superoxide Dismutase
(cerebrospinal fluid)
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