Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women.
Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: This was a prospective study of 26,836 initially healthy women followed for 13 years for incident type 2 diabetes (n = 1,687). Baseline lipids were measured directly and lipoprotein size and concentration by NMR. Cox regression models included nonlipid risk factors (age, race, smoking, exercise, education, menopause, blood pressure, BMI, family history, A1C, and C-reactive protein). NMR lipoproteins were also examined after further adjusting for standard lipids. RESULTS: Incident diabetes was significantly associated with baseline HDL cholesterol, triglycerides, and NMR-measured size and concentration of LDL, IDL, HDL, and VLDL particles. The associations of these particles differed substantially by size. Small LDL(NMR) and small HDL(NMR) were positively associated with diabetes (quintile 5 vs. 1 [adjusted hazard ratios and 95% CIs], 4.04 [3.21-5.09] and 1.84 [1.54-2.19], respectively). By contrast, large LDL(NMR) and large HDL(NMR) were inversely associated (quintile 1 vs. 5, 2.50 [2.12-2.95] and 4.51 [3.68-5.52], respectively). For VLDL(NMR), large particles imparted higher risk than small particles (quintile 5 vs. 1, 3.11 [2.35-4.11] and 1.31 [1.10-1.55], respectively). Lipoprotein particle size remained significant after adjusting for standard lipids and nonlipid factors. CONCLUSIONS:
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Authors | Samia Mora, James D Otvos, Robert S Rosenson, Aruna Pradhan, Julie E Buring, Paul M Ridker |
Journal | Diabetes
(Diabetes)
Vol. 59
Issue 5
Pg. 1153-60
(May 2010)
ISSN: 1939-327X [Electronic] United States |
PMID | 20185808
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Lipoproteins
- Lipoproteins, HDL
- Lipoproteins, IDL
- Lipoproteins, LDL
- Lipoproteins, VLDL
- Triglycerides
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Topics |
- Cholesterol, HDL
(chemistry, metabolism)
- Diabetes Mellitus, Type 2
(metabolism)
- Female
- Humans
- Lipoproteins
(chemistry, metabolism)
- Lipoproteins, HDL
(chemistry, metabolism)
- Lipoproteins, IDL
(chemistry, metabolism)
- Lipoproteins, LDL
(chemistry, metabolism)
- Lipoproteins, VLDL
(chemistry, metabolism)
- Magnetic Resonance Spectroscopy
(methods)
- Middle Aged
- Molecular Weight
- Prospective Studies
- Triglycerides
(chemistry, metabolism)
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