Abstract | BACKGROUND: OBJECTIVE: DESIGN: We carried out a 6-wk randomized, placebo-controlled, 2 x 2 factorial intervention study of atorvastatin (40 mg/d) and fish oils (4 g/d) on VLDL apo C-III kinetics in the postabsorptive state in 39 abdominally obese men using intravenous administration of d(3)-leucine. VLDL apo C-III isotopic enrichments were measured by using gas chromatography-mass spectrometry with kinetic parameters derived by using a multicompartmental model. RESULTS:
Atorvastatin significantly (P < 0.05, main effect) increased the VLDL apo C-III fractional catabolic rate (+0.06 +/- 0.003 pools/d) without significantly altering its production rate (-0.14 +/- 0.18 mg . kg(-1) . d(-1)), accounting for a significant reduction in plasma VLDL apo C-III pool size (-44 +/- 17 mg/L). Fish-oil supplementation significantly decreased plasma triglycerides but did not significantly alter plasma VLDL apo C-III concentrations or kinetic parameters. Combination treatment provided no additional effect on VLDL apo C-III concentrations or kinetics compared with atorvastatin alone. CONCLUSIONS:
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Authors | Dick C Chan, Minh N Nguyen, Gerald F Watts, Esther Mm Ooi, P Hugh R Barrett |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 91
Issue 4
Pg. 900-6
(Apr 2010)
ISSN: 1938-3207 [Electronic] United States |
PMID | 20181806
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Apolipoprotein C-III
- Cholesterol, VLDL
- Fatty Acids, Omega-3
- Heptanoic Acids
- Pyrroles
- Triglycerides
- Atorvastatin
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Topics |
- Adult
- Aged
- Anticholesteremic Agents
(pharmacology, therapeutic use)
- Apolipoprotein C-III
(blood, metabolism)
- Atorvastatin
- Cholesterol, VLDL
(blood)
- Dietary Supplements
- Double-Blind Method
- Drug Therapy, Combination
- Fatty Acids, Omega-3
(pharmacology, therapeutic use)
- Heptanoic Acids
(pharmacology, therapeutic use)
- Humans
- Male
- Middle Aged
- Obesity, Abdominal
(blood, drug therapy)
- Pyrroles
(pharmacology, therapeutic use)
- Triglycerides
(blood)
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