Abstract | OBJECTIVE: CASE SUMMARY: DISCUSSION: CF is caused by a genetic mutation resulting in a dysfunctional or absent CF transmembrane conductance regulator that normally functions as a chloride channel. This results in viscous secretions in multiple organ systems including the lungs and intestinal tract. Accumulation of viscous intestinal contents contributes to constipation, which is common among adults with CF and can sometimes lead to intestinal obstruction. Lubiprostone is indicated for chronic constipation and works by activating type 2 chloride channels (ClC-2) in the intestinal tract. Because it utilizes an alternate chloride channel, lubiprostone may be especially effective for constipation in patients with CF. CONCLUSIONS:
Lubiprostone provides an additional option for the treatment of constipation in adults with CF. Its use in the CF population deserves further study.
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Authors | Catherine E O'Brien, Paula J Anderson, Cindy D Stowe |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 44
Issue 3
Pg. 577-81
(Mar 2010)
ISSN: 1542-6270 [Electronic] United States |
PMID | 20179256
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chloride Channels
- Cystic Fibrosis Transmembrane Conductance Regulator
- Lubiprostone
- Alprostadil
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Topics |
- Adult
- Alprostadil
(adverse effects, analogs & derivatives, pharmacology, therapeutic use)
- Chloride Channels
(drug effects, metabolism)
- Constipation
(drug therapy, etiology)
- Cystic Fibrosis
(complications, genetics, physiopathology)
- Cystic Fibrosis Transmembrane Conductance Regulator
(genetics, metabolism)
- Female
- Humans
- Intestinal Obstruction
(drug therapy, etiology)
- Lubiprostone
- Male
- Secondary Prevention
- Treatment Outcome
- Young Adult
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