Anticlastogenic effect of apigenin in human lymphocytes treated with ethinylestradiol.

Abstract

In the present study the antigenotoxic effect of apigenin was studied against a genotoxic dose of ethinylestradiol using the damage parameters of chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and cell cycle kinetics (CCK). Human peripheral blood lymphocytes were cultured and treated with 10 microM of ethinylestradiol along with doses of 5, 10, 15 and 20 microM of apigenin. A clear decrease in the genotoxic damage induced by ethinylestradiol was observed with increasing doses of apigenin, suggesting a protective role for apigenin during ethinylestradiol therapy.

• Authors: Yasir Hasan Siddique, Gulshan Ara, Tanveer Beg, Mohammad Afzal
• Journal: Fitoterapia (Fitoterapia) Vol. 81 Issue 6 Pg. 590-4 (Sep 2010) ISSN: 1873-6971 [Electronic] Netherlands
• PMID: 20176089 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright (c) 2010 Elsevier B.V. All rights reserved.

Chemical References

• Mutagens
• Ethinyl Estradiol
• Apigenin

Topics

• Adult
• Apigenin (pharmacology)
• Cell Cycle (drug effects)
• Chromosome Aberrations (chemically induced, drug effects)
• Drug Evaluation, Preclinical
• Ethinyl Estradiol (antagonists & inhibitors)
• Female
• Humans
• Lymphocytes (drug effects)
• Mutagens (pharmacology)
• Sister Chromatid Exchange (drug effects)
• Young Adult