Synthesis of poly(vinyl alcohol)/C(60) and poly(N-vinylpyrrolidone)/C(60) nanohybrids as potential photodynamic cancer therapy agents.

Abstract

Well-defined poly(vinyl acetate) (PVAc) and poly(N-vinylpyrrolidone)-co-poly(vinyl acetate) (PNVP-co-PVAc) chains end-capped by Co(acac)(2) (acac=acetylacetonate) and prepared by cobalt-mediated radical polymerization (CMRP) are grafted onto a fullerene. Homolytic Co-C bond cleavage of the polymer chain ends at 30 degrees C releases the polymeric radicals that add onto C(60), thereby leading to the corresponding PVAc/C(60) and PNVP-co-PVAc/C(60) nanohybrids. The [polymer-Co(acac)(2)]/[C(60)] molar ratio was varied to adjust the structure of the nanohybrids, and more particularly the number of grafted arms. Finally, the potential of the hydrosoluble PVOH/C(60) nanohybrids, which result from the methanolysis of the ester groups of PVAc/C(60), and of the PNVP-co-PVAc/C(60) nanohybrids as photosensitizers for photodynamic therapy (PDT), was approached. First, photobleaching tests demonstrated the ability of these nanohybrids to produce singlet oxygen upon irradiation, which can play a role in cell damage. Second, cell viability assays demonstrated that both types of nanohybrids are deprived of intrinsic cytotoxicity in the dark, whereas they promoted significant cell mortality when subjected to light treatment. The selective response of these materials to irradiation makes them promising compounds for PDT.

• Authors: Marie Hurtgen, Antoine Debuigne, Ange Mouithys-Mickalad, Robert Jérôme, Christine Jérôme, Christophe Detrembleur
• Journal: Chemistry, an Asian journal (Chem Asian J) Vol. 5 Issue 4 Pg. 859-68 (Apr 01 2010) ISSN: 1861-471X [Electronic] Germany
• PMID: 20140908 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Photosensitizing Agents
• Pyrrolidinones
• Singlet Oxygen
• Cobalt
• N-vinyl-2-pyrrolidinone
• Polyvinyl Alcohol

Topics

• Cell Line
• Cobalt (chemistry)
• Humans
• Nanoparticles (chemistry)
• Photochemotherapy
• Photosensitizing Agents (chemistry)
• Polyvinyl Alcohol (chemistry)
• Pyrrolidinones (chemistry)
• Quantum Theory
• Singlet Oxygen (metabolism)