Highly selective fusion and accumulation of hybrid liposomes into primary effusion lymphoma cells along with induction of apoptosis.

Abstract

Primary effusion lymphoma (PEL) is an aggressive neoplasm caused by human herpes virus-8 infection, and is generally resistant to chemotherapy. Hybrid liposomes, composed of dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene (21) dodecyl ether (C12(EO)21) (HL-21), were rapidly accumulated in the membrane of PEL cells. HL-21 also increased membrane fluidity of PEL cells, and induced caspase-3 activation along with cell death. These results suggest that HL-21 should be an effective and attractive regent for PEL treatment.

• Authors: Tomomi Towata, Yuji Komizu, Shinya Suzu, Ryuichi Ueoka, Seiji Okada
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 393 Issue 3 Pg. 445-8 (Mar 12 2010) ISSN: 1090-2104 [Electronic] United States
• PMID: 20138834 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2010 Elsevier Inc. All rights reserved.

Chemical References

• Liposomes
• Polidocanol
• Polyethylene Glycols
• Dimyristoylphosphatidylcholine

Topics

• Apoptosis
• Cell Line, Tumor
• Cell Membrane (metabolism)
• Dimyristoylphosphatidylcholine (chemistry, metabolism)
• Humans
• Liposomes (chemistry, metabolism)
• Lymphoma, Primary Effusion (metabolism)
• Membrane Fluidity
• Membrane Fusion
• Polidocanol
• Polyethylene Glycols (chemistry, metabolism)