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Sinonasal tumor in 3 dogs after successful topical treatment for frontal sinus aspergillosis.

Abstract
Three dogs diagnosed with aspergillosis developed sinonasal tumors several months after successful treatment with topical clotrimazole solution. Chronic rhinosinusitis was also detected in all cases prior to diagnosis of sinonasal tumors. The inflammatory response to Aspergillus, clotrimazole treatment, and chronic inflammation after treatment are discussed as possible neoplastic promoting factors.
AuthorsValentina Greci, Damiano Stefanello, Mauro Di Giancamillo, Carlo M Mortellaro
JournalThe Canadian veterinary journal = La revue veterinaire canadienne (Can Vet J) Vol. 50 Issue 11 Pg. 1191-4 (Nov 2009) ISSN: 0008-5286 [Print] Canada
PMID20119545 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • Clotrimazole
Topics
  • Administration, Intranasal
  • Administration, Topical
  • Animals
  • Antifungal Agents (adverse effects, therapeutic use)
  • Aspergillosis (drug therapy)
  • Clotrimazole (adverse effects, therapeutic use)
  • Dog Diseases (chemically induced, drug therapy)
  • Dogs
  • Fatal Outcome
  • Female
  • Frontal Sinus (microbiology, pathology)
  • Male
  • Paranasal Sinus Neoplasms (chemically induced, veterinary)

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