HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intravenous colistin sulfate: a rarely used form of polymyxin E for the treatment of severe multidrug-resistant Gram-negative bacterial infections.

Abstract
In recent reports polymyxins have been considered an effective and safe treatment option for the management of multidrug-resistant (MDR) Gram-negative bacterial infections. Here we report our clinical experience with the use of intravenous colistin sulfate in critically ill patients hospitalized from January 2006 to October 2008, as a last treatment resort in China, and assess its effectiveness and adverse effects. Fifteen patients who suffered from severe infections caused by MDR or pandrug-resistant (PDR) Gram-negative bacteria (13 isolates of Acinetobacter baumannii, 4 isolates of Pseudomonas aeruginosa and 2 isolates of Klebsiella pneumoniae), unresponsive to the initial empirical regimens, were treated with colistin sulfate (daily dose of 1.28 +/- 0.25 million IU and duration of 22.3 +/- 6.2 days), based on sensitivity results. The treatment resulted in a good clinical response in 73.3%, microbiological clearance in 60% and mortality in 20%. Possible nephrotoxicity occurred in 1 patient and no patients developed neurotoxicity. In conclusion, intravenous colistin sulfate is a safe and viable alternative for the treatment of severe infections due to sensitive MDR Gram-negative bacteria.
AuthorsJie Huang, Yao-Qing Tang, Jing-Yong Sun
JournalScandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 42 Issue 4 Pg. 260-5 (Apr 2010) ISSN: 1651-1980 [Electronic] England
PMID20085424 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Colistin
Topics
  • Adult
  • Aged
  • Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
  • Central Nervous System Diseases (chemically induced)
  • China
  • Colistin (administration & dosage, adverse effects, therapeutic use)
  • Critical Illness
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Gram-Negative Bacteria (drug effects)
  • Gram-Negative Bacterial Infections (drug therapy, microbiology, mortality)
  • Humans
  • Injections, Intravenous
  • Kidney (drug effects)
  • Kidney Diseases (chemically induced)
  • Male
  • Middle Aged
  • Retrospective Studies
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: