Abstract |
In recent reports polymyxins have been considered an effective and safe treatment option for the management of multidrug-resistant (MDR) Gram-negative bacterial infections. Here we report our clinical experience with the use of intravenous colistin sulfate in critically ill patients hospitalized from January 2006 to October 2008, as a last treatment resort in China, and assess its effectiveness and adverse effects. Fifteen patients who suffered from severe infections caused by MDR or pandrug-resistant (PDR) Gram-negative bacteria (13 isolates of Acinetobacter baumannii, 4 isolates of Pseudomonas aeruginosa and 2 isolates of Klebsiella pneumoniae), unresponsive to the initial empirical regimens, were treated with colistin sulfate (daily dose of 1.28 +/- 0.25 million IU and duration of 22.3 +/- 6.2 days), based on sensitivity results. The treatment resulted in a good clinical response in 73.3%, microbiological clearance in 60% and mortality in 20%. Possible nephrotoxicity occurred in 1 patient and no patients developed neurotoxicity. In conclusion, intravenous colistin sulfate is a safe and viable alternative for the treatment of severe infections due to sensitive MDR Gram-negative bacteria.
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Authors | Jie Huang, Yao-Qing Tang, Jing-Yong Sun |
Journal | Scandinavian journal of infectious diseases
(Scand J Infect Dis)
Vol. 42
Issue 4
Pg. 260-5
(Apr 2010)
ISSN: 1651-1980 [Electronic] England |
PMID | 20085424
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Colistin
|
Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage, adverse effects, therapeutic use)
- Central Nervous System Diseases
(chemically induced)
- China
- Colistin
(administration & dosage, adverse effects, therapeutic use)
- Critical Illness
- Drug Resistance, Multiple, Bacterial
- Female
- Gram-Negative Bacteria
(drug effects)
- Gram-Negative Bacterial Infections
(drug therapy, microbiology, mortality)
- Humans
- Injections, Intravenous
- Kidney
(drug effects)
- Kidney Diseases
(chemically induced)
- Male
- Middle Aged
- Retrospective Studies
- Treatment Outcome
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