Abstract | BACKGROUND: METHODS: DU 145, LNCaP and PC-3 prostate cancer cells were treated with ARC, Siomycin A and thiostrepton to evaluate their activity as single agents or in combination with ABT-737 and bortezomib to measure their synergistic potential in anti-proliferative and cell cycle assays. Chou-Talalay method was used to quantitate the synergistic interaction. Western blot method was used to determine Mcl-1 and FoxM1 expression and caspase-3 cleavage. RESULTS: CONCLUSIONS:
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Authors | Bulbul Pandit, Andrei L Gartel |
Journal | The Prostate
(Prostate)
Vol. 70
Issue 8
Pg. 825-33
(Jun 01 2010)
ISSN: 1097-0045 [Electronic] United States |
PMID | 20058240
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- 4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide
- ABT-737
- Antineoplastic Agents
- Biphenyl Compounds
- Boronic Acids
- Nitrophenols
- Nucleosides
- Peptides
- Piperazines
- Pyrazines
- Pyrimidines
- Sulfonamides
- Bortezomib
- siomycin A
- Thiostrepton
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Topics |
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Biphenyl Compounds
(pharmacology)
- Blotting, Western
- Boronic Acids
(pharmacology)
- Bortezomib
- Cell Cycle
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Cells, Cultured
- Dose-Response Relationship, Drug
- Drug Synergism
- Humans
- Male
- Nitrophenols
(pharmacology)
- Nucleosides
(pharmacology)
- Peptides
(pharmacology)
- Piperazines
(pharmacology)
- Prostate
(drug effects)
- Pyrazines
(pharmacology)
- Pyrimidines
(pharmacology)
- Sulfonamides
(pharmacology)
- Thiostrepton
(pharmacology)
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