[Protective role of leptin in acute gastric ulcers].

Abstract

There are few data concerning protective effects of leptin on gastric epithelium treated with necrotic factors: ethanol, bile salts and hiperosmotic solutions. Further investigations are needed to establish the role of hormone leptin in gastroprotection and in the process of chronic gastric ulcers healing in animals. Exogenous leptin administration plays protective effects against 75% ethanol damage in gastric epithelium. Nitric oxide is involved in gastroprotective effects of leptin and CCK.

• Authors: Agata Ptak-Belowska, Tomasz Brzozowski, Robert Pajdo, Michał Pawlik, Sławomir Kwiecień, Danuta Drozdowicz, Wiesław W Pawlik
• Journal: Folia medica Cracoviensia (Folia Med Cracov) Vol. 49 Issue 3-4 Pg. 23-35 ( 2008) ISSN: 0015-5616 [Print] Poland
• Vernacular Title: Ochronna rola leptyny w ostrych wrzodach zoładka.
• PMID: 20050576 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Leptin

Topics

• Acute Disease
• Animals
• Anti-Ulcer Agents (administration & dosage)
• Gastric Mucosa (metabolism)
• Leptin (administration & dosage, metabolism)
• Random Allocation
• Rats
• Rats, Wistar
• Regional Blood Flow (drug effects)
• Stomach Ulcer (drug therapy, metabolism, prevention & control)