Abstract | BACKGROUND: METHODS AND RESULTS: We performed a nested case-control study in the prospective EPIC-Norfolk cohort. Cases were apparently healthy men and women, aged 45 to 79 years, who developed fatal or nonfatal CAD (n=882). Controls remained free of CAD (n=1490). Overall, systemic prolactin levels did not differ between cases and controls, and people in the highest prolactin tertile did not have a significantly increased risk of developing future CAD (in men, odds ratio, 1.21; 95% CI, 0.92 to 1.61; in women, odds ratio, 1.12; 95% CI, 0.76 to 1.64). However, in a separate immunohistochemical study, the presence of prolactin receptors could be demonstrated in postmortem human coronary artery plaques (preliminary data). CONCLUSIONS:
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Authors | Anne Q Reuwer, Marcel ThB Twickler, Barbara A Hutten, Frederique W Molema, Nicholas J Wareham, Geesje M Dallinga-Thie, Roman L Bogorad, Vincent Goffin, Mijke Smink-Bol, John J P Kastelein, S Matthijs Boekholdt, Kay-Tee Khaw |
Journal | Circulation. Cardiovascular genetics
(Circ Cardiovasc Genet)
Vol. 2
Issue 4
Pg. 389-95
(Aug 2009)
ISSN: 1942-3268 [Electronic] United States |
PMID | 20031611
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Prolactin
- Prolactin
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Topics |
- Aged
- Atherosclerosis
(pathology)
- Case-Control Studies
- Cohort Studies
- Coronary Artery Disease
(epidemiology)
- Coronary Vessels
(pathology)
- Female
- Humans
- Male
- Middle Aged
- Odds Ratio
- Prolactin
(blood)
- Receptors, Prolactin
(metabolism)
- Risk Factors
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