The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids.

Abstract

OBJECTIVE:

The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids.

STUDY DESIGN:

This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and > or = 25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome.

RESULTS:

Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of > or = 25. The composite outcome occurred more frequently in the body mass index of > or = 2 5 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding.

CONCLUSION:

Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.

• Authors: Jason N Hashima, Yinglei Lai, Ronald J Wapner, Yoram Sorokin, Donald J Dudley, Alan Peaceman, Catherine Y Spong, Jay D Iams, Kenneth J Leveno, Margaret Harper, Steve N Caritis, Michael Varner, Menachem Miodovnik, Brian M Mercer, John M Thorp, Mary J O'Sullivan, Susan M Ramin, Marshall Carpenter, Dwight J Rouse, Baha Sibai, Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 202 Issue 3 Pg. 263.e1-5 (Mar 2010) ISSN: 1097-6868 [Electronic] United States
• PMID: 20022589 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
• Copyright: Copyright 2010 Mosby, Inc. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Dexamethasone
• Betamethasone

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Betamethasone (therapeutic use)
• Body Mass Index
• Bronchopulmonary Dysplasia (epidemiology, prevention & control)
• Dexamethasone (therapeutic use)
• Enterocolitis, Necrotizing (epidemiology, prevention & control)
• Female
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (epidemiology, prevention & control)
• Injections, Intramuscular
• Intracranial Hemorrhages (epidemiology, prevention & control)
• Leukomalacia, Periventricular (epidemiology, prevention & control)
• Obesity (epidemiology)
• Pregnancy
• Respiratory Distress Syndrome, Newborn (epidemiology, prevention & control)
• Retinopathy of Prematurity (epidemiology, prevention & control)