Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: Using a single nucleotide polymorphism (SNP; rs41279104, also called ex1c), we conducted a genetic association analysis of case-control samples (325 MDD patients, 154 BP patients and 807 controls) in the Japanese population. In addition, we performed an association analysis between NOS1 and the efficacy of fluvoxamine treatment in 117 MDD patients. We defined a clinical response as a decrease of more than 50% in baseline SIGH-D (Structured Interview Guide for the Hamilton Rating Scale for Depression) score within 8 weeks, and clinical remission as an SIGH-D score of less than 7 at 8 weeks. RESULTS: We did not detect a significant association between NOS1 and MDD, BP or the fluvoxamine therapeutic response in MDD in allele/genotype-wise analysis. CONCLUSIONS: We did not detect an association between only one marker (rs41279104) in NOS1 and Japanese mood disorder patients and fluvoxamine response, but sample sizes were probably too small to allow a meaningful test. Moreover, because we did not perform an association analysis based on linkage disequilibrium and a mutation scan of NOS1, a replication of the study using a larger sample and based on linkage disequilibrium may be required for conclusive results.
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Authors | Takenori Okumura, Taro Kishi, Tomo Okochi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomoko Tsunoka, Toshiya Inada, Norio Ozaki, Nakao Iwata |
Journal | Neuropsychobiology
(Neuropsychobiology)
Vol. 61
Issue 2
Pg. 57-63
( 2010)
ISSN: 1423-0224 [Electronic] Switzerland |
PMID | 20016223
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents, Second-Generation
- Nitric Oxide Synthase Type I
- Fluvoxamine
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Topics |
- Adult
- Aged
- Antidepressive Agents, Second-Generation
(therapeutic use)
- Chi-Square Distribution
- Depressive Disorder, Major
(drug therapy, genetics)
- Female
- Fluvoxamine
(therapeutic use)
- Gene Frequency
- Genome-Wide Association Study
(methods)
- Genotype
- Humans
- Japan
(ethnology)
- Male
- Middle Aged
- Nitric Oxide Synthase Type I
(genetics)
- Pharmacogenetics
- Polymorphism, Single Nucleotide
(genetics)
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