A rice variety (HYJA-Ri4) enhances arterial thrombus formation in an animal model of thrombosis.

Abstract

Epidemiological evidence exists for a causative role of inappropriate diets in the development and clinical outcome of thrombotic diseases. Our previous studies have shown that some fruits and vegetables have antithrombotic activity. As rice is a principal ingredient of everyday food in Japan, the aim of the present study was to determine rice varieties with antithrombotic effect. Western-style high-fat diet containing flour prepared from whole-grain rice of different varieties was fed to atherosclerosis-prone (apolipoprotein E- and low density lipoprotein receptor-deficient) mice for 3 months. A laser-induced carotid-artery thrombosis model was used. None of the five tested rice varieties showed an antithrombotic effect. The effect of HYJA-Ri1, HYJA-Ri2, HYJA-Ri3 and HYJA-Ri5 rice on experimental thrombus formation did not differ significantly from the controls. However, HYJA-Ri4 rice significantly enhanced the thrombotic reaction (p = 0.0078), thus having a prothrombotic effect. Our findings suggest that HYJA-Ri4 rice should not be included in an antithrombotic diet.

• Authors: Aki Naemura, Yoshinobu Ijiri, Mitsuhiro Kodama, Yoshinori Honda, Junichiro Yamamoto
• Journal: Pathophysiology of haemostasis and thrombosis (Pathophysiol Haemost Thromb) Vol. 36 Issue 5 Pg. 241-4 ( 2008) ISSN: 1424-8840 [Electronic] Switzerland
• PMID: 19996633 (Publication Type: Journal Article)
• Copyright: Copyright 2009 S. Karger AG, Basel.

Chemical References

• Apolipoproteins E
• Receptors, LDL

Topics

• Animals
• Apolipoproteins E (deficiency)
• Carotid Artery Diseases
• Diet
• Disease Models, Animal
• Mice
• Oryza (adverse effects)
• Receptors, LDL (deficiency)
• Thrombosis (etiology, prevention & control)