Abstract | OBJECTIVES:
Acute pancreatitis (AP) is characterized by pancreatic microcirculatory and secretory disturbances. As galanin can modulate pancreatic vascular perfusion, we sought to determine if galanin plays a role in AP. METHODS: RESULTS:
Galantide ameliorated AP, reducing all indices by 25% to 40%, whereas galanin was without effect. In galanin knockout mice, all indices of AP were reduced 25% to 50% compared with wild-type littermates. Galanin administration to the knockout mice exacerbated AP such that it was comparable with the AP induced in the wild-type mice. Conversely, administration of galantide to the galanin knockout mice did not affect the AP, whereas AP was ameliorated in the wild-type mice. The 3 galanin receptor subtypes are expressed in mouse pancreas, with receptor subtype 3 expression predominating. CONCLUSIONS: These data implicate a role for galanin in AP and suggest a potential clinical application for galanin antagonists in treatment.
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Authors | Mayank Bhandari, Anthony C Thomas, Damian J Hussey, Xin Li, Surendra P Jaya, Charmaine M Woods, Ann C Schloithe, George C Mayne, Colin J Carati, James Toouli, Christopher J Ormandy, Gino T P Saccone |
Journal | Pancreas
(Pancreas)
Vol. 39
Issue 2
Pg. 182-7
(Mar 2010)
ISSN: 1536-4828 [Electronic] United States |
PMID | 19959967
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Receptors, Galanin
- galantide
- Substance P
- Galanin
- Ceruletide
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Topics |
- Acute Disease
- Animals
- Ceruletide
- Disease Models, Animal
- Female
- Galanin
(administration & dosage, analogs & derivatives, antagonists & inhibitors, deficiency, genetics, metabolism, pharmacology)
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Pancreas
(drug effects, metabolism, pathology)
- Pancreatitis
(chemically induced, genetics, metabolism, pathology, prevention & control)
- RNA, Messenger
(metabolism)
- Receptors, Galanin
(metabolism)
- Severity of Illness Index
- Substance P
(analogs & derivatives, pharmacology)
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