Pharmacological evaluation of novel indole-2-carboxamides as potent lipid-lowering agents in Triton-WR-1339-induced hyperlipidemic rats.

Abstract

The lipid-lowering effects of two novel antihyperlipidemic agents, BMI2C [N-(4-benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide] and DDMI2C [N-(9,10-dihydro-9,10-dioxoanthracen-2-yl)-5-methoxy-1H-indole-2-carboxamide], were studied using hyperlipidemic rats as an experimental model; hyperlipidemia was developed by intraperitoneal injection of Triton WR-1339 (200 mg/kg body weight). At a dose of 15 mg/kg body weight, BMI2C and DDMI2C significantly reduced elevated plasma triglyceride levels after 7 and 24 h. Furthermore, BMI2C and DDMI2C significantly reduced elevated plasma total cholesterol levels after 24 h. Interestingly, high-density lipoprotein-cholesterol levels were significantly increased in all treated groups. These findings indicate that the two studied novel compounds have a promising potential in the treatment of hyperlipidemia and atherosclerosis.

• Authors: Tariq Al-Qirim, Moyad Shahwan, Ghassan Shattat, Yusuf Al-Hiari, Ghassan Abu-Sheikha, Syed Zaidi
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 2009 Sep-Oct Vol. 64 Issue 9-10 Pg. 619-25 ISSN: 0939-5075 [Print] Germany
• PMID: 19957427 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amides
• Hypolipidemic Agents
• Lipids
• Polyethylene Glycols
• tyloxapol

Topics

• Amides (pharmacology, therapeutic use)
• Animals
• Hyperlipidemias (chemically induced, drug therapy)
• Hypolipidemic Agents (pharmacology)
• Lipids (blood, classification)
• Magnetic Resonance Spectroscopy
• Male
• Polyethylene Glycols (administration & dosage)
• Rats
• Rats, Wistar
• Spectrometry, Mass, Electrospray Ionization
• Spectrophotometry, Infrared