Glutathione S-transferase P1 and alpha gene variants; role in susceptibility and tumor size development of oral cancer.

Abstract

BACKGROUND:

The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.

METHODS:

Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure these 4 gene polymorphisms in 274 controls and 164 oral cancer patients.

RESULTS:

Individuals with at least 1 varied G allele of GSTP1 had a 1.53-fold risk (95% confidence interval [CI] = 1.01-2.31) of developing oral cancer compared with patients with wild-type A/A homozygotes. Oral cancer patients with at least 1 varied T allele of GSTA1 gene had a 0.42-fold risk (95% CI = 0.18-0.95) of having a tumor size >2 cm compared with patients with C/C homozygotes.

CONCLUSIONS:

The varied G allele of GSTP1 may be considered as a factor contributing to increased susceptibility, whereas the T allele of GSTA1 could be a protective factor for tumor size progression in Taiwanese with oral cancer.

• Authors: Mu-Kuan Chen, Hsiu-Ting Tsai, Tsung-Te Chung, Shih-Chi Su, Te-Yu Kao, Hsien-Chun Tseng, Te-Hsiung Liu, Hui-Ling Chiou, Shun-Fa Yang
• Journal: Head & neck (Head Neck) Vol. 32 Issue 8 Pg. 1079-87 (Aug 2010) ISSN: 1097-0347 [Electronic] United States
• PMID: 19953622 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2009 Wiley Periodicals, Inc. Head Neck, 2010.

Chemical References

• glutathione S-transferase T1
• GSTA1 protein, human
• GSTP1 protein, human
• Glutathione S-Transferase pi
• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Adult
• Aged
• Case-Control Studies
• Cohort Studies
• Female
• Genetic Predisposition to Disease
• Glutathione S-Transferase pi (genetics)
• Glutathione Transferase (genetics)
• Humans
• Male
• Middle Aged
• Mouth Neoplasms (enzymology, genetics, pathology)
• Neoplasm Staging
• Polymorphism, Genetic (genetics)
• Taiwan