Abstract | PURPOSE: The purpose of this study was to evaluate the effect of a single dose of intravitreal diclofenac, a potent nonsteroidal antiinflammatory drug, on visual acuity and central macular thickness in patients with macular edema of various etiologies. METHODS: RESULTS: After 2 weeks, visual acuity improved in 3 (30%) eyes (P = 0.78), did not change in 3 (30%) eyes, and decreased in 3 (30%) eyes. After 4 weeks, improvement of best-corrected visual acuity occurred in 5 (50%) eyes (P = 0.07), but in 3 eyes (30%), best-corrected visual acuity did not change, and in 1 eye (10%), visual acuity decreased. After 8 weeks, visual acuity improved in 7 (70%) eyes (P = 0.019), got worse in 1 eye (10%), and did not change in 2 eyes (20%). Central macular thickness did not decrease significantly at 8 weeks. On the basis of electroretinography, no significant changes in the amplitude of a-wave or b-wave in relation to baseline were noticed in any eye. CONCLUSION: Up to 8 weeks, intravitreal diclofenac treatment of eyes with macular edema of various etiologies yielded prominent improvement in visual acuity but was not associated with a significant decrease in central macular thickness. No toxic effect of intravitreal diclofenac was observed.
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Authors | Masoud Soheilian, Saeed Karimi, Alireza Ramezani, Gholam A Peyman |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 30
Issue 3
Pg. 509-15
(Mar 2010)
ISSN: 1539-2864 [Electronic] United States |
PMID | 19952986
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Diclofenac
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Topics |
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects)
- Diclofenac
(administration & dosage, adverse effects)
- Electroretinography
- Female
- Fluorescein Angiography
- Humans
- Injections
- Macular Edema
(drug therapy, etiology, physiopathology)
- Male
- Middle Aged
- Pilot Projects
- Prospective Studies
- Retina
(physiology)
- Visual Acuity
(physiology)
- Vitreous Body
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