Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy.

Abstract

Autoimmune pancreatitis (AIP) is often associated with systemic extrapancreatic lesions, and the concept of IgG4-related autoimmune disease has been proposed. We report a 62-year-old woman with AIP associated with various extrapancreatic lesions during a long-term clinical course. These extrapancreatic lesions occurred after the withdrawal of steroid therapy. Sclerosing sialadenitis occurred before AIP, whereas autoimmune sensorineural hearing loss, allergic purpura and endocapillary proliferative glomerulonephritis occurred after AIP. However, no relapse was observed for 5 years after the start of maintenance therapy with prednisolone and azathioprine.

• Authors: Itaru Naitoh, Takahiro Nakazawa, Hirotaka Ohara, Hitoshi Sano, Tomoaki Ando, Kazuki Hayashi, Hajime Tanaka, Fumihiro Okumura, Katsuyuki Miyabe, Michihiro Yoshida, Satoru Takahashi, Takashi Joh
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 48 Issue 23 Pg. 2003-7 ( 2009) ISSN: 1349-7235 [Electronic] Japan
• PMID: 19952482 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones
• Azathioprine

Topics

• Adrenal Cortex Hormones (administration & dosage)
• Autoimmune Diseases (drug therapy, immunology, pathology)
• Azathioprine (administration & dosage)
• Drug Therapy, Combination
• Female
• Hearing Loss, Sensorineural (drug therapy, immunology, pathology)
• Humans
• IgA Vasculitis (drug therapy, immunology, pathology)
• Middle Aged
• Pancreatitis (drug therapy, immunology, pathology)
• Sialadenitis (drug therapy, immunology, pathology)
• Time Factors
• Treatment Outcome