Phospholipid transfer protein (PLTP) is an important modulator of
lipoprotein metabolism, including interparticle
phospholipid transfer, remodeling of
HDL, cholesterol and
phospholipid efflux from peripheral tissues, and the production of hepatic VLDL. PLTP also plays an important role in
inflammation and oxidative stress. Accordingly, PLTP has been implicated in the development of
atherosclerosis. In this study, we evaluated the association between PLTP activity and
lipoprotein metabolism in a Chinese patients cohort with or without
coronary heart disease (CHD group n = 407, control group n = 215), the PLTP activity was measured and PLTP genotyping was screened for sequence anomalies by PCR. We found that human plasma PLTP activity was negatively associated with plasma HDL and
apoA-I levels, and positively associated with plasma TG,
apoB and
apoE levels. We also found that PLTP rs2294213 polymorphism was tended to be associated with increased plasma PLTP activity.