In situ gelation of supramolecular hydrogel for anti-tumor drug delivery.

Abstract

A supramolecular injectable hydrogel was fabricated. The hydrogel was in situ gelated by the host-guest interaction between alpha-cyclodextrins (alpha-CDs) and methylated poly(ethylene glycol) grafted poly(alpha,beta-malic acid) (mPEG-g-PMA). The hydrogel was characterized by (1)NMR, XRD, DSC, TGA and SEM. The results showed that the polyrotaxanes of alpha-CDs/mPEG-g-PMA acted as physical crosslink sites in the hydrogel. Anti-tumor drug doxorubicin hydrochloride (DOX) was loaded in the hydrogel. The release and anti-tumor effect were studied in vitro. The burst release of DOX was restrained obviously. The sustaining release time lasted more than 3 d and the cell viability decreased greatly. This hydrogel is a promising injectable hydrogel for minimally invasive therapeutic drug delivery.

• Authors: Bin He, Jing Zeng, Yu Nie, Li Ji, Rui Wang, Yuan Li, Yao Wu, Li Li, Gang Wang, Xianglin Luo, Zhirong Zhang, Zhongwei Gu
• Journal: Macromolecular bioscience (Macromol Biosci) Vol. 9 Issue 12 Pg. 1169-75 (Dec 08 2009) ISSN: 1616-5195 [Electronic] Germany
• PMID: 19911347 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Hydrogels

Topics

• Antineoplastic Agents (administration & dosage)
• Calorimetry, Differential Scanning
• Cell Line, Tumor
• Drug Carriers
• Humans
• Hydrogels
• Magnetic Resonance Spectroscopy
• Microscopy, Electron, Scanning
• X-Ray Diffraction