Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: We highlight the feed-forward mechanisms by which gastrin and CCK2 receptor expression are upregulated during inflammation and in gastrointestinal cancers, summarize gastrin's proinflammatory role by inducing the production of cyclooxgenase-2 (COX-2) and interleukin-8 (IL-8), and relate evidence suggesting that gastrin and their receptors modulate the function of immune cells and fibroblasts following cellular stress, injury, repair, as well as during cancer progression. SUMMARY: We discuss trends for future studies directed toward the elucidation of gastrin peptides' role in regulating intercellular molecular signaling mechanisms between local and circulating immune cells, fibroblasts, epithelial cells, and other cell types in the microenvironments of inflammation-related cancers. Elucidation of the molecular and cellular pathways that relate inflammation with cancer may provide additional opportunities to develop complementary therapies that target the inflammatory microenvironment of the cancer.
|
Authors | Celia Chao, Mark R Hellmich |
Journal | Current opinion in endocrinology, diabetes, and obesity
(Curr Opin Endocrinol Diabetes Obes)
Vol. 17
Issue 1
Pg. 33-9
(Feb 2010)
ISSN: 1752-2978 [Electronic] England |
PMID | 19907321
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
|
Chemical References |
- Cytokines
- Gastrins
- Inflammation Mediators
- Receptor, Cholecystokinin B
|
Topics |
- Animals
- Cocarcinogenesis
- Colorectal Neoplasms
(etiology, physiopathology)
- Cytokines
(physiology)
- Feedback, Physiological
- Gastrins
(physiology)
- Gastritis
(complications, etiology, physiopathology)
- Gastrointestinal Neoplasms
(etiology, physiopathology)
- Helicobacter Infections
(complications)
- Helicobacter pylori
- Humans
- Inflammation Mediators
(physiology)
- Leukocytes
(immunology, physiology)
- Receptor, Cholecystokinin B
(physiology)
|