Takotsubo cardiomyopathy after nasal application of epinephrine--a magnetic resonance study.

Abstract

Takotsubo cardiomyopathy (TTC), which is characterized by transient left ventricular impairment in absence of coronary artery disease, is usually associated with emotional or physical stress, supposing that catecholamines are involved in pathophysiology. The present article reports on two cases with characteristic features of TTC following nasal application of epinephrine during nasal surgery. Both subjects serially underwent cardiovascular magnetic resonance, which revealed myocardial vasodilatation, capillary leak and regional edema in the acute state and ruled out focal necrosis. Thus, the present cases both stress the catecholamine hypothesis in the pathogenesis of TTC and underline the potential of CMR to diagnose and monitor TTC.

• Authors: Florian von Knobelsdorff-Brenkenhoff, Hassan Abdel-Aty, Jeanette Schulz-Menger
• Journal: International journal of cardiology (Int J Cardiol) Vol. 145 Issue 2 Pg. 308-309 (Nov 19 2010) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 19906451 (Publication Type: Case Reports, Letter)
• Copyright: Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Epinephrine

Topics

• Administration, Intranasal
• Adult
• Epinephrine (administration & dosage, adverse effects)
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Takotsubo Cardiomyopathy (chemically induced, diagnosis)