HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

p52-Independent nuclear translocation of RelB promotes LPS-induced attachment.

Abstract
The NF-kappaB signaling pathways have a critical role in the development and progression of various cancers. In this study, we demonstrated that the small cell lung cancer cell line (SCLC) H69 expressed a unique NF-kappaB profile as compared to other cancer cell lines. The p105/p50, p100/p52, c-Rel, and RelB protein and mRNA transcripts were absent in H69 cells but these cells expressed RelA/p65. The activation of H69 cells by lipopolysaccharide (LPS) resulted in the induction of RelB and p100 expression. The treatment also induced the nuclear translocation of RelB without the processing of p100 to p52. Furthermore, LPS-induced beta1 integrin expression and cellular attachment through an NF-kappaB-dependent mechanism. Blocking RelB expression prevented the increase in the expression of beta1 integrin and the attachment of H69. Taken together, the results suggest that RelB was responsible for the LPS-mediated attachment and may play an important role in the progression of some cancers.
AuthorsT Saito, C Y Sasaki, L J Rezanka, P Ghosh, D L Longo
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 391 Issue 1 Pg. 235-41 (Jan 01 2010) ISSN: 1090-2104 [Electronic] United States
PMID19903458 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
CopyrightPublished by Elsevier Inc.
Chemical References
  • Integrin beta1
  • Lipopolysaccharides
  • NF-kappa B p52 Subunit
  • Transcription Factor RelB
Topics
  • Active Transport, Cell Nucleus
  • Cell Adhesion
  • Cell Line, Tumor
  • Cell Nucleus (metabolism)
  • Humans
  • Integrin beta1 (biosynthesis)
  • Lipopolysaccharides (immunology)
  • Lung Neoplasms (immunology, metabolism, pathology)
  • NF-kappa B p52 Subunit (metabolism)
  • Small Cell Lung Carcinoma (immunology, metabolism, pathology)
  • Transcription Factor RelB (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: