Abstract |
In primary biliary cirrhosis (PBC) serum markers other than anti-mitochondrial antibodies (AMA) are promising in terms of disease severity and comorbidities, as well represented by anti-nuclear antibodies (ANA). The aim of the present study was thus to evaluate the prevalence and clinical significance of a large profile of serum autoantibodies in PBC sera. We utilized 69 sera from European patients with PBC (including 20 AMA-negative) and 297 sera from geographically and sex-matched healthy controls. All sera were tested for the presence of ANA and autoantibodies associated with thrombophilia, vasculitis, and gastrointestinal disease. Autoantibodies other than AMA were detected in 53/69 (76%) PBC sera vs. 105/297 (35%) among controls. The prevalence of ANA (targeting dsDNA, Sm, chromatin, ribosomal-P, RNP, SmRNP, SSA, SSB, and centromere) and thrombophilia-associated autoantibodies (i.e. anti-beta2GPI, phosphatydilserine, prothrombin) was common among patients with PBC. When clinical features were compared, the presence of anti- prothrombin IgM was associated with a worse prognosis as represented by a higher Mayo score. We demonstrate an increased prevalence of ANA and thrombophilia-associated autoantibodies in PBC sera and an association between the latter autoantibodies and PBC stage. The role of thrombophilia-associated antibodies will warrant further studies, based in particular on the incidence of portal hypertension at early stages of PBC.
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Authors | Nancy Agmon-Levin, Yinon Shapira, Carlo Selmi, Ori Barzilai, Maya Ram, Martine Szyper-Kravitz, Sara Sella, Bat-Sheva Porat Katz, Pierre Youinou, Yves Renaudineau, Bruno Larida, Pietro Invernizzi, M Eric Gershwin, Yehuda Shoenfeld |
Journal | Journal of autoimmunity
(J Autoimmun)
Vol. 34
Issue 1
Pg. 55-8
(Feb 2010)
ISSN: 1095-9157 [Electronic] England |
PMID | 19897339
(Publication Type: Journal Article)
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Copyright | Copyright 2009 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antibodies, Antinuclear
- Immunoglobulin M
- Prothrombin
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Topics |
- Aged
- Antibodies, Antinuclear
(blood)
- Cross-Sectional Studies
- Disease Progression
- Female
- Humans
- Immunoglobulin M
(blood)
- Liver Cirrhosis, Biliary
(blood, diagnosis, immunology, physiopathology)
- Male
- Middle Aged
- Prognosis
- Prothrombin
(immunology)
- Risk Assessment
- Thrombophilia
- Vasculitis
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