Severe exacerbation of multiple self-healing squamous epithelioma (Ferguson-Smith disease) with radiotherapy, which was successfully treated with acitretin.

Abstract

We describe the challenging case of a patient presenting with extensive, eruptive mid-facial squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) consequent to radiotherapy. Our patient had a personal and family history of multiple KAs and SCCs. Multiple self-healing squamous epithelioma, otherwise known as Ferguson-Smith disease, was diagnosed. This case presented a therapeutic challenge to preserve tissue and avoid severe facial disfigurement. We found oral acitretin to be the treatment of choice.

• Authors: S J Robertson, S J Bashir, G Pichert, A Robson, S Whittaker
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 35 Issue 4 Pg. e100-2 (Jun 2010) ISSN: 1365-2230 [Electronic] England
• PMID: 19874360 (Publication Type: Case Reports, Journal Article)

Chemical References

• Keratolytic Agents
• Acitretin

Topics

• Acitretin (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, pathology, radiotherapy)
• Facial Neoplasms (drug therapy, pathology, radiotherapy)
• Humans
• Keratoacanthoma (drug therapy, pathology, radiotherapy)
• Keratolytic Agents (therapeutic use)
• Male
• Middle Aged
• Neoplasms, Multiple Primary (drug therapy, pathology, radiotherapy)
• Neoplasms, Radiation-Induced (drug therapy)
• Neoplastic Syndromes, Hereditary (drug therapy, pathology, radiotherapy)
• Skin Neoplasms (drug therapy, pathology, radiotherapy)