A new polymorphism in the GRP78 is not associated with HBV invasion.

Abstract

AIM:

To examine the association between -86 bp (T > A) in the glucose-regulated protein 78 gene (GRP78) and hepatitis B virus (HBV) invasion.

METHODS:

DNA was genotyped for the single-nucleotide polymorphism by polymerase chain reaction followed by sequencing in a sample of 382 unrelated HBV carriers and a total of 350 sex- and age-matched healthy controls. Serological markers for HBV infection were determined by enzyme-linked immunosorbent assay kits or clinical chemistry testing.

RESULTS:

The distributions of allelotype and genotype in cases were not significantly different from those in controls. In addition, our findings suggested that neither alanine aminotransferase/hepatitis B e antigen nor HBV-DNA were associated with the allele/genotype variation in HBV infected individuals.

CONCLUSION:

-86 bp T > A polymorphism in GRP78 gene is not related to the clinical risk and acute exacerbation of HBV invasion.

• Authors: Xiao Zhu, Yi Wang, Tao Tao, Dong-Pei Li, Fei-Fei Lan, Wei Zhu, Dan Xie, Hsiang-Fu Kung
• Journal: World journal of gastroenterology (World J Gastroenterol) Vol. 15 Issue 39 Pg. 4958-61 (Oct 21 2009) ISSN: 2219-2840 [Electronic] United States
• PMID: 19842229 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Viral
• Endoplasmic Reticulum Chaperone BiP
• HSPA5 protein, human
• Heat-Shock Proteins
• Hepatitis B Antibodies
• Hepatitis B e Antigens
• Alanine Transaminase

Topics

• Adult
• Alanine Transaminase (blood)
• Asian People (genetics)
• Case-Control Studies
• China (epidemiology)
• DNA, Viral (blood)
• Endoplasmic Reticulum Chaperone BiP
• Enzyme-Linked Immunosorbent Assay
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Heat-Shock Proteins (genetics)
• Hepatitis B (diagnosis, ethnology, genetics)
• Hepatitis B Antibodies (blood)
• Hepatitis B e Antigens (blood)
• Hepatitis B virus (genetics, immunology, pathogenicity)
• Humans
• Logistic Models
• Male
• Odds Ratio
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Assessment
• Young Adult