AM-111 prevents hearing loss from semicircular canal injury in otitis media.

Abstract

OBJECTIVES/HYPOTHESIS:

Iatrogenic semicircular canal (SC) transection during mastoidectomy for chronic otitis media often leads to profound hearing loss. AM-111, an apoptosis inhibitor, has been shown to mitigate hearing loss resulting from a variety of inner ear injuries. The goal of this study was to determine if round window application of AM-111 following SC transection in the presence of Pseudomonas aeruginosa otitis media (PA-OM) may reduce the associated hearing loss.

STUDY DESIGN:

Prospective, randomized, controlled study in an animal model.

METHODS:

PA-OM was induced bilaterally in 34 guinea pigs. After 3 days, both bullae were opened and the lateral SC of one ear was transected. AM-111 or vehicle was applied topically to the round window of the ear that had undergone SC transection. Hearing was assessed with auditory brainstem responses.

RESULTS:

The mean change in hearing thresholds was significantly less in transected ears treated with AM-111 than those receiving vehicle alone when testing with clicks (22.1 dB vs. 35.0 dB; P = .019) and at 4kHz (11.3 dB vs. 40.0 dB; P = .021). A similar trend was shown with 16 kHz tone pips (27.7 dB vs. 41.1 dB; P = .119).

CONCLUSIONS:

AM-111 prevents hearing loss from SC transection in the guinea pig model of PA-OM.

• Authors: Tyler C Grindal, Edith M Sampson, Patrick J Antonelli
• Journal: The Laryngoscope (Laryngoscope) Vol. 120 Issue 1 Pg. 178-82 (Jan 2010) ISSN: 1531-4995 [Electronic] United States
• PMID: 19821539 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptides
• D-JNKI-1

Topics

• Administration, Topical
• Animals
• Apoptosis (drug effects)
• Guinea Pigs
• Hearing Loss (etiology, prevention & control)
• Otitis Media (complications)
• Peptides (administration & dosage, therapeutic use)
• Prospective Studies
• Pseudomonas Infections (complications)
• Pseudomonas aeruginosa
• Random Allocation
• Semicircular Canals (injuries)