The burden of hospitalizations and clinic visits for rotavirus disease in children aged <5 years in the Philippines.

Abstract

BACKGROUND:

Recent data on the burden of hospitalization and clinic visits for rotavirus gastroenteritis are needed to support the decision to introduce rotavirus vaccine in the Philippines.

METHODS:

From 2005 through 2006, children aged <5 years with acute diarrhea who attended 1 of 7 clinics and/or hospitals in Muntinlupa City, the Philippines, were enrolled. Clinical and demographic data were collected, and a stool specimen was obtained for rotavirus testing and typing for G and P antigens. The incidences of different clinical outcomes of rotavirus gastroenteritis were determined for 3 townships under surveillance and were extrapolated to the Philippines with use of national data sets.

RESULTS:

The prevalence of rotavirus was 31% (171/560) among children hospitalized with diarrhea, 30% (155/520) among those who presented to the emergency department, and 15% (56/385) among those who presented to a clinic. The annual estimated incidence (per 100,000 children aged <5 years) of rotavirus gastroenteritis in outpatient, emergency department, and inpatient settings was 755, 451, and 279, respectively. Of 274 strains, 50 (18%) were nontypeable. Of the 128 strains that underwent G and P typing, 98% belong to the globally common strains G3P[P], G2P[4], and G1P[8].

CONCLUSIONS:

The burden of rotavirus gastroenteritis in the Philippines is high and is predominantly caused by strains against which current vaccines have shown good efficacy, suggesting that routine immunization will have a large impact on rotavirus disease burden.

• Authors: Celia C Carlos, Marianette T Inobaya, Joseph S Bresee, Marietta L Lagrada, Agnettah M Olorosa, Carl D Kirkwood, Marc-Alain Widdowson
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 200 Suppl 1 Pg. S174-81 (Nov 01 2009) ISSN: 1537-6613 [Electronic] United States
• PMID: 19817598 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Child, Preschool
• Cost of Illness
• Gastroenteritis (epidemiology)
• Genotype
• Hospitalization
• Humans
• Incidence
• Infant
• Infant, Newborn
• Philippines (epidemiology)
• Rotavirus (classification)
• Rotavirus Infections (epidemiology, virology)