Early and mid-term clinical outcomes with the CATANIA coronary stent system vs. bare metal stents in patients with coronary artery disease.

Abstract

BACKGROUND:

The potential for the CATANIA (CAT) stent to be an alternative to both bare-metal stents (BMS) and drug-eluting stents (DES) has been recently demonstrated in the Assessment of The LAtest Non-Thrombogenic Angioplasty stent (ATLANTA) first-in-human study. The aim of the present study was to compare short-term outcomes of patients treated with the CAT stent with those treated with BMS.

METHODS:

Based on an internal registry, the 30-day and 6-month risk-adjusted outcomes for patients who received the CAT stent (n=254) were compared against outcomes of a historical cohort of patients who received BMS (n=552) between January 2001 and December 2001.

RESULTS:

At 30 days, use of BMS vs. the CAT stent resulted in borderline significant differences with respect to major adverse cardiac and cerebrovascular events (MACCE) and cardiac death or myocardial infarction. At 6 months, BMS showed a statistically significant higher adjusted risk of MACCE (HR 2.79, 95% CIs 1.20-6.48, P=.017) and no differences with respect to the subcomponent end points. The cumulative incidence of definite stent thrombosis (Academic Research Consortium defined) at 6 months was 0.39% for the CAT stent and 2.35% for the BMS.

CONCLUSIONS:

This study confirms the favorable early and mid-term safety profile and the high-level efficacy of the CAT stent in the treatment of de novo coronary lesions seen in the ATLANTA trial. The use of stents with a nanothin Polyzene-F surface treatment provided improved results with respect to BMS and lower risk of acute and subacute stent thrombosis.

• Authors: Davide Capodanno, Alessio La Manna, Maria Elena Di Salvo, Alessandra Sanfilippo, Thierry Corcos, Corrado Tamburino
• Journal: Cardiovascular revascularization medicine : including molecular interventions (Cardiovasc Revasc Med) 2009 Oct-Dec Vol. 10 Issue 4 Pg. 216-20 ISSN: 1878-0938 [Electronic] United States
• PMID: 19815167 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Coated Materials, Biocompatible
• Metals

Topics

• Aged
• Angioplasty, Balloon, Coronary (adverse effects, instrumentation, mortality)
• Cerebrovascular Disorders (etiology, mortality)
• Coated Materials, Biocompatible
• Cohort Studies
• Coronary Angiography
• Coronary Artery Disease (diagnostic imaging, mortality, therapy)
• Female
• Humans
• Kaplan-Meier Estimate
• Male
• Metals
• Middle Aged
• Myocardial Infarction (etiology, mortality)
• Proportional Hazards Models
• Prosthesis Design
• Registries
• Risk Assessment
• Risk Factors
• Stents
• Thrombosis (etiology)
• Time Factors
• Treatment Outcome