Abstract |
The effect of curcumin, a dietary antioxidant was studied against kainic acid (KA)-induced seizures and on markers of oxidative stress. Rats were administered KA (10 mg/kg, ip) and observed for behavioral changes, incidence and latency of convulsions and mortality over four hours. The rats were thereafter sacrificed for estimation of oxidative stress parameters; malondialdehyde (MDA) and glutathione (GSH). Curcumin was administered 30 min before KA at doses of 50, 100 and 200 mg/kg, ip. KA induced long-lasting seizures and associated symptoms. The brain level of MDA was significantly (P < 0.05) raised after KA administration (536 +/- 44 nmol/g wet tissue) as compared to saline treated group (200 +/- 36 nmol/g wet tissue) and significantly decreased the levels of GSH. Pretreatment with curcumin (100 and 200 mg/kg, ip) significantly increased the latency of seizures (120 + 20 min and 11 5+/- 5.7 min respectively) as compared to the vehicle treated KA group. Curcumin (100 and 200 mg/ kg, ip) significantly prevented the increase in MDA levels and ameliorated the fall in glutathione. Curcumin at the dose of 50 mg/kg had no effect on any of oxidative stress parameters. The study reports the potential antiepileptic effect of antioxidant curcumin.
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Authors | Yogendra K Gupta, Seema Briyal, Monisha Sharma |
Journal | Indian journal of physiology and pharmacology
(Indian J Physiol Pharmacol)
2009 Jan-Mar
Vol. 53
Issue 1
Pg. 39-46
ISSN: 0019-5499 [Print] India |
PMID | 19810575
(Publication Type: Journal Article)
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Chemical References |
- Malondialdehyde
- Glutathione
- Curcumin
- Kainic Acid
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Topics |
- Animals
- Behavior, Animal
(drug effects)
- Brain
(drug effects, metabolism)
- Curcumin
(pharmacology, therapeutic use)
- Dose-Response Relationship, Drug
- Glutathione
(metabolism)
- Kainic Acid
- Male
- Malondialdehyde
(metabolism)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Wistar
- Seizures
(chemically induced, prevention & control)
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